Glutathione in Health and Disease Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective Toxicology Research (RSC Publishing) Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Is Glutathione the Master Antioxidant? Heres What Science Says Part Two Amazon.com: The Glutathione Revolution: Fight Disease, Slow Aging, and Increase Energy with the Master Antioxidant (Audible Audio Edition): Nayan Patel PharmD PharmD, Mark Hyman introduction MD MD, Gary Tiedemann, Balance: Books